부산대학교 도서관

Simple Summary: This study investigated the immune response in ovarian cancer (OC) patients before and after surgery. The aim was to explore how the immune system is affected by surgery, with a specific focus on peripheral blood mononuclear cells (PBMCs). An analysis of blood samples revealed pre-operative immune imbalances in OC patients that were further exacerbated post-operatively. The study results suggest that OC patients experience a degree of immune suppression, particularly during the early post-operative period. This indicates a potential window of vulnerability that could facilitate cancer progression. Our findings may contribute to the development of better treatment strategies and improved outcomes for OC patients. Surgical treatment is a cornerstone of ovarian cancer (OC) therapy and exerts a substantial influence on the immune system. Immune responses also play a pivotal and intricate role in OC progression. The aim of this study was to investigate the dynamics of immune-related protein expression and the activity of peripheral blood mononuclear cells (PBMCs) in OC patients, both before surgery and during the early postoperative phase. The study cohort comprised 23 OC patients and 20 non-cancer controls. A comprehensive analysis of PBMCs revealed significant pre-operative downregulation in the mRNA expression of multiple immune-related proteins, including interleukins, PD-1, PD-L1, and HO-1. This was followed by further dysregulation during the first 5 post-operative days. Although most serum interleukin concentrations showed only minor changes, a distinct increase in IL-6 and HO-1 levels was observed post-operatively. Reduced metabolic and phagocytic activity and increased production of reactive oxygen species (ROS) were observed on day 1 post-surgery. These findings suggest a shift towards immune tolerance during the early post-operative phase of OC, potentially creating a window for treatment. Further research into post-operative PBMC activity could lead to the development of new or improved treatment strategies for OC. [ABSTRACT FROM AUTHOR]