부산대학교 도서관

This article explores the natural history of Ras-associated autoimmune leukoproliferative disorder (RALD), a rare condition caused by mutations in the NRAS or KRAS genes. RALD is characterized by lymphadenopathy, splenomegaly, persistent leucocytosis, and autoimmune symptoms. The article discusses the challenges in diagnosing and monitoring RALD patients, as some may develop juvenile myelomonocytic leukemia (JMML) or acute myeloid leukemia (AML), while others may experience spontaneous improvement. The article presents a case study of a 22-year-old male with RALD, providing a clinical history and a detailed analysis of his immune profile. The study emphasizes the importance of exploring somatic gene variants in patients with specific immunological profiles and suggests that an integrated approach combining clinical parameters, functional assays, and longitudinal assessment of additional mutations may help predict disease progression. The findings contribute to the understanding of RALD and may enhance monitoring and treatment strategies for patients with this rare condition. [Extracted from the article]