부산대학교 도서관

Background: Despite historical evidence of blinding trachoma, there have been no widespread contemporary surveys of trachoma prevalence in the northern states of Sudan. We aimed to conduct district-level surveys in this vast region in order to map the extent of the problem and estimate the need for trachoma control interventions to eliminate blinding trachoma. Methods and Findings: Separate, population based cross-sectional surveys were conducted in 88 localities (districts) in 12 northern states of Sudan between 2006 and 2010. Two-stage cluster random sampling with probability proportional to size was used to select the sample. Trachoma grading was done using the WHO simplified grading system. Key prevalence indicators were trachomatous inflammation-follicular (TF) in children aged 1–9 years and trachomatous trichiasis (TT) in adults aged 15 years and above. The sample comprised 1,260 clusters from which 25,624 households were surveyed. A total of 106,697 participants (81.6% response rate) were examined for trachoma signs. TF prevalence was above 10% in three districts and between 5% and 9% in 11 districts. TT prevalence among adults was above 1% in 20 districts (which included the three districts with TF prevalence >10%). The overall number of people with TT in the population was estimated to be 31,072 (lower and upper bounds = 26,125–36,955). Conclusion: Trachoma mapping is complete in the northern states of Sudan except for the Darfur States. The survey findings will facilitate programme planning and inform deployment of resources for elimination of trachoma from the northern states of Sudan by 2015, in accordance with the Sudan Federal Ministry of Health (FMOH) objectives. Author Summary: Trachoma is an infectious disease which is caused by a bacterium, Chlamydia trachomatis and is the leading cause of preventable blindness, estimated to be responsible for 2.9% of blindness globally. The World Health Organization (WHO) recommends an integrated strategy for control and elimination of blinding trachoma known as SAFE, which stands for: surgery; antibiotics; facial cleanliness; and environmental improvement. In order to identify districts where trachoma is a public health problem, we undertook 88 district-level surveys in 12 northern states of Sudan. Our findings revealed that interventions to prevent blinding trachoma are recommended in 14 out of 88 districts where the prevalence of trachomatous inflammation-follicular (TF) in children aged 1–9 years exceeded the WHO thresholds for intervention. Services to provide surgery to those with trachomatous trichiasis (TT) should be prioritized in 20 districts where prevalence of TT in adults exceeded 1%. These findings are important since they will help the Sudan Federal Ministry of Health (FMOH) to prioritize resources for elimination of trachoma. [ABSTRACT FROM AUTHOR]