부산대학교 도서관

Simple Summary: This review seeks to explore and understand palmitoylation, a crucial cellular process, and its significant role in cancer cell development and death. The research team will focus on understanding the complex relationships between palmitoylation and cancer formation, particularly how specific family proteins and enzymes contribute to, or counteract, the process. With the advent of innovative detection techniques, our understanding of these processes has grown more nuanced and sophisticated. The research will also spotlight potential agents that show promise in targeting palmitoylation for cancer therapy, offering a glimpse into potentially groundbreaking treatment strategies. Through this comprehensive review, the authors aim not only to highlight the transformative potential of studying palmitoylation in cancer treatment but also to deepen the scientific community's understanding of the molecular mechanisms at play in cancer. In this comprehensive survey, we delve into the multifaceted role of palmitoylation across various cell death modalities in the oncological context, from its intricate correlations with tumorigenesis, steered by the Asp-His-His-Cys tetrapeptide motif (DHHC) family, to the counter-process of depalmitoylation mediated by enzymes like Palmitoyl protein thioesterase-1 (PPT1). Innovations in detection methodologies have paralleled our growing understanding, transitioning from rudimentary techniques to sophisticated modern methods. Central to our discourse are agents like Ezurpimtrostat (GNS561) and dimeric chloroquine (DC661), promising heralds in palmitoylation-targeted cancer therapy. Collectively, this review accentuates palmitoylation's transformative potential in oncology, foreshadowing groundbreaking therapeutic strategies and deepening our molecular comprehension of cancer dynamics. [ABSTRACT FROM AUTHOR]