학술논문
Music compensates for altered gene expression in age-related cognitive disorders.
Document Type
Article
Author
Gómez-Carballa, Alberto; Navarro, Laura; Pardo-Seco, Jacobo; Bello, Xabier; Pischedda, Sara; Viz-Lasheras, Sandra; Camino-Mera, Alba; Currás, María José; Ferreirós, Isabel; Mallah, Narmeen; Rey-Vázquez, Sara; Redondo, Lorenzo; Dacosta-Urbieta, Ana; Caamaño-Viña, Fernando; Rivero-Calle, Irene; Rodriguez-Tenreiro, Carmen; Martinón-Torres, Federico; Salas, Antonio
Source
Subject
*GENE expression
*COGNITION disorders
*MILD cognitive impairment
*ALZHEIMER'S disease
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Language
ISSN
2045-2322
Abstract
Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n = 60), and main genes/pathways were compared to those dysregulated in mild cognitive impairment (MCI) and Alzheimer's disease (AD) as revealed by a multi-cohort study (n = 1269 MCI/AD and controls). Music was associated with 2.3 times more whole-genome gene expression, particularly on neurodegeneration-related genes, in ACD than in controls. Co-expressed gene-modules and pathways analysis demonstrated that music impacted autophagy, vesicle and endosome organization, biological processes commonly dysregulated in MCI/AD. Notably, the data indicated a strong negative correlation between musically-modified genes/pathways in ACD and those dysregulated in MCI/AD. These findings highlight the compensatory effect of music on genes/biological processes affected in MCI/AD, providing insights into the molecular mechanisms underlying the benefits of music on these disorders. [ABSTRACT FROM AUTHOR]