학술논문
Long-term effects of subthalamic nucleus deep brain stimulation on speech in Parkinson's disease.
Document Type
Article
Author
Gessani, Annalisa; Cavallieri, Francesco; Fioravanti, Valentina; Campanini, Isabella; Merlo, Andrea; Di Rauso, Giulia; Damiano, Benedetta; Scaltriti, Sara; Bardi, Elisa; Corni, Maria Giulia; Antonelli, Francesca; Cavalleri, Francesca; Molinari, Maria Angela; Contardi, Sara; Menozzi, Elisa; Fraternali, Alessandro; Versari, Annibale; Biagini, Giuseppe; Fraix, Valérie; Pinto, Serge
Source
Subject
*DEEP brain stimulation
*INTELLIGIBILITY of speech
*PARKINSON'S disease
*SUBTHALAMIC nucleus
*SPEECH
*PREHABILITATION
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Language
ISSN
2045-2322
Abstract
Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment in advanced Parkinson's Disease (PD). However, the effects of STN-DBS on speech are still debated, particularly in the long-term follow-up. The objective of this study was to evaluate the long-term effects of bilateral STN-DBS on speech in a cohort of advanced PD patients treated with bilateral STN-DBS. Each patient was assessed before surgery through a neurological evaluation and a perceptual-acoustic analysis of speech and re-assessed in the long-term in different stimulation and drug conditions. The primary outcome was the percentage change of speech intelligibility obtained by comparing the postoperative on-stimulation/off-medication condition with the preoperative off-medication condition. Twenty-five PD patients treated with bilateral STN-DBS with a 5-year follow-up were included. In the long-term, speech intelligibility stayed at the same level as preoperative values when compared with preoperative values. STN-DBS induced a significant acute improvement of speech intelligibility (p < 0.005) in the postoperative assessment when compared to the on-stimulation/off-medication and off-stimulation/off-medication conditions. These results highlight that STN-DBS may handle speech intelligibility even in the long-term. [ABSTRACT FROM AUTHOR]