학술논문
The relationship between serum levels of miR?200a and miR?152 and the prognosis of patients with gesta? tional trophoblastic neoplasia undergoing chemotherapy.
Document Type
Article
Source
Subject
*GESTATIONAL trophoblastic disease
*CANCER chemotherapy
*COMBINATION drug therapy
*PROGNOSIS
*TROPHOBLASTIC tumors
*TUMORS
*INTERNATIONAL organization
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Language
Chinese
ISSN
1006-5725
Abstract
Objective.This study mainly explores the role of serum microRNA-200a (miR-200a) and microRNA-152 (miR-152) in gestational trophoblastic tumors (GTN) prognosis. Methods.One-hundred GTN chemotherapy patients who treated in our hospital were collected as the observation group, according to the efficacy of chemotherapy, patients were divided into the good prognosis group (80 cases) and the poor prognosis group (20 cases), 103 healthy women who underwent physical examination were collected as the control group. Real-time fluorescence quantitative PCR method was applied to detect the expression levels of miR-200a and miR-152 in serum. Results.The serum miR-200a expression level in the observation group was higher than that in the control group, while the miR-152 expression level was lower than that in the control group (P < 0.05). With the prolongation of chemotherapy time, the expression level of miR-200a in the serum of the good prognosis group and the poor prognosis group decreased sequentially, while the expression level of miR-152 increased sequentially (P < 0.05). The expression level of miR-200a in the serum of the poor prognosis group before and after chemotherapy were higher than that of the good prognosis group, while the expression level of miR-152 was lower than that of the good prognosis group (P < 0.05). There was a statistically significant difference in the International Federation of Obstetrics and Gynecology (FIGO) prognosis score and pre chemotherapy blood HCG levels between the group with good prognosis and the group with poor prognosis (P < 0.05). The AUC of predicting poor prognosis in GTN chemotherapy patients with serum miR-200a and miR-152 expression levels before chemotherapy alone and in combination were 0.793, 0.844, and 0.887, respectively. MiR-200a, miR-152, and FIGO prognosis scores7 are associated with poor prognosis in GTN chemotherapy patients (P < 0.05). Conclusion.High expression of miR-200a and low expression of miR-152 before chemotherapy may be associated with poor prognosis in GTN chemotherapy patients, which can provide reference for the evaluation of chemotherapy prognosis. [ABSTRACT FROM AUTHOR]