학술논문

Where does the gadolinium go? A review into the excretion and retention of intravenous gadolinium.
Document Type
Article
Source
Journal of Medical Imaging & Radiation Oncology. Oct2023, Vol. 67 Issue 7, p742-752. 11p.
Subject
*GADOLINIUM
*CONTRAST-enhanced magnetic resonance imaging
*PATIENT experience
*CONTRAST media
*EXCRETION
Language
ISSN
1754-9477
Abstract
Summary: Gadolinium‐based contrast agents (GBCAs) are commonly used in medical imaging. Most intravenously (IV) administered gadolinium is excreted via the kidneys, and pathological retention in renal failure leading to nephrogenic systemic fibrosis (NSF) is well described. More recently, retention of gadolinium in the body in the absence of renal disease has been identified, with unknown clinical consequences. Many patients are aware of this, either through the media or via comprehensive consent documentation. Some internet sites, without hard evidence, have suggested a constellation of possible symptoms associated with GBCA retention. Recent experience with patients ascribing symptoms to a contrast‐enhanced MRI examination prompted this review of the fate of injected GBCA after MRI study, and of information available to patients online regarding gadolinium retention. [ABSTRACT FROM AUTHOR]