부산대학교 도서관

However, histopathologically, dermatitis herpetiformis presents with subepidermal neutrophilic spongiosis with granular immunoglobulin A deposits most commonly at the dermal papillae with direct immunofluorescence.[3] This patient's histopathologic specimen, showing the direct immunofluorescence of intercellular IgG and C3 deposits within the epidermis, was more consistent with pemphigus vulgaris or pemphigus foliaceus. A 61-year-old male presented with extensive pruritic annular pink plaques with erosion and excoriation involving the abdomen, back, all extremities, scalp, and face (Fig. On the other hand, desmoglein 1 antibodies are implicated in the acantholytic process of pemphigus foliaceus.[4] The pathogenesis of pemphigus herpetiformis remains unclear, but Costal et al. found that 50% reported cases of pemphigus herpetiformis were positive for desmoglein 1 antibodies compared to 11% positive for desmoglein 3 antibodies.[2] Ishii et al. reported that desmoglein 1 and desmoglein 3 are major targets for autoantibodies in pemphigus herpetiformis when evaluating serum samples of patients with pemphigus herpetiformis. [Extracted from the article]