학술논문

Applications of engineered exosomes in drugging noncoding RNAs for cancer therapy.
Document Type
Article
Source
Chemical Biology & Drug Design. Nov2023, Vol. 102 Issue 5, p1257-1275. 19p.
Subject
*NON-coding RNA
*EXOSOMES
*CANCER treatment
*CIRCULAR RNA
*CANCER prevention
*CANCER invasiveness
Language
ISSN
1747-0277
Abstract
Noncoding RNAs (ncRNAs) are engaged in key cell biological and pathological events, and their expression alteration is connected to cancer progression both directly and indirectly. A huge number of studies have mentioned the significant role of ncRNAs in cancer prevention and therapy that make them an interesting subject for cancer therapy. However, there are several limitations, including delivery, uptake, and short half‐life, in the application of ncRNAs in cancer treatment. Exosomes are introduced as promising options for the delivery of ncRNAs to the target cells. In this review, we will briefly discuss the application and barriers of ncRNAs. After that we will focus on exosome‐based ncRNAs delivery and their advantages as well as the latest achievements in drugging ncRNAs with exosomes. [ABSTRACT FROM AUTHOR]