학술논문
Detection of blood–brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2.
Document Type
Article
Author
Source
Subject
*BLOOD-brain barrier
*COVID-19
*SARS-CoV-2
*
*
Language
ISSN
0001-6322
Abstract
Overall, we find autopsy evidence of widespread BBB disruption in the brains of individuals with history of COVID-19 infection, but no detectable virus in tissue sections. Detection of blood-brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2 Nevertheless, the extensive fibrinogen extravasation we observed in context of SARS-CoV-2 infection was in excess of that observed in normal aging, with widespread and substantial fibrinogen extravasation in both brain gray and white matter in our youngest COVID+, aged just 41 years (Fig. Amplifier labeling Alexa Fluor 488 green was used as the negative control marking tissue autofluorescence to minimize false positivity. b In contrast, no SARS-CoV-2 viral RNA was detected in the brain tissue. [Extracted from the article]