부산대학교 도서관

OBJECTIVE:To clarify the role of body mass index (BMI, kg/m2) adjustment in predictive models for cardiovascular events that add high-sensitivity C-reactive protein (hs-CRP) to the 10-y Framingham Coronary Heart Disease Risk Score (FCRS).DESIGN:A cross-sectional study in a group of apparently healthy individuals.SUBJECTS:In all, 1512 apparently healthy individuals (955 men and 557 women) at a respective age of 49.7±10.6 and 50.6±9.6 y.RESULTS:The Pearson correlation between hs-CRP and the calculated 10-y FCRS was lower when adjusted for BMI. This reduction was especially noted in women where it dropped from 0.247 to 0.09. The dominant role of hs-CRP concentrations was also noted in a linear regression model, again, especially noted in women (drop of the standardized coefficient from 0.517 for BMI to 0.08 for the FCRS).CONCLUSIONS:The correlation between hs-CRP and the 10-y FCRS is partly related to the presence of obesity. We raise the possibility that the addition of BMI to the predictive model of FCRS might attenuate the cost-effectiveness of CRP measurements for this specific risk assessment.International Journal of Obesity (2005) 29, 772–777. doi:10.1038/sj.ijo.0802939 Published online 29 March 2005 [ABSTRACT FROM AUTHOR]