학술논문
Durable Anti-Vi IgG and IgA Antibody Responses in 15-Month-Old Children Vaccinated With Typhoid Conjugate Vaccine in Burkina Faso.
Document Type
Article
Author
Ouedraogo, Alphonse; Diarra, Amidou; Nébié, Issa; Barry, Nouhoun; Kabore, Jean Moise; Tiono, Alfred B; Datta, Shrimati; Liang, Yuanyuan; Mayo, Ifayet; Oshinsky, Jennifer J; Tracy, J Kathleen; Girmay, Tsion; Pasetti, Marcela F; Jamka, Leslie P; Neuzil, Kathleen M; Sirima, Sodiomon B; Laurens, Matthew B
Source
Subject
*IMMUNOGLOBULINS
*VACCINES
*TYPHOID fever
*ANTIBODY formation
*RANDOMIZED controlled trials
*BURKINABE
*BLIND experiment
*TYPHOID vaccines
*STATISTICAL sampling
*CHILDREN
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Language
ISSN
2048-7193
Abstract
We assessed anti-Vi IgG/IgA responses to typhoid conjugate vaccine (TCV) in children enrolled in a double-blind randomized controlled, phase 2 trial in Burkina Faso. Anti-Vi IgG seroconversion and anti-Vi IgA titers were higher in TCV than control recipients at 30–35 months post-vaccination. TCV induces durable immunity in Burkinabe children vaccinated at 15 months. [ABSTRACT FROM AUTHOR]