학술논문
Ancestral Origin and Dissemination Dynamics of Reemerging Toxigenic Vibrio cholerae, Haiti.
Document Type
Article
Author
Mavian, Carla N.; Tagliamonte, Massimiliano S.; Alam, Meer T.; Sakib, S. Nazmus; Cash, Melanie N.; Moir, Monika; Jimenez, Juan Perez; Riva, Alberto; Nelson, Eric J.; Cato, Emilie T.; Ajayakumar, Jayakrishnan; Louis, Rigan; Curtis, Andrew; Beau De Rochars, V. Madsen; Rouzier, Vanessa; Pape, Jean William; de Oliveira, Tulio; Morris, J. Glenn; Salemi, Marco; Ali, Afsar
Source
Subject
*CHOLERA
*VIBRIO cholerae
*HERD immunity
*INFRASTRUCTURE (Economics)
*PRIME ministers
*PUBLIC health
*
*
*
*
*
Language
ISSN
1080-6040
Abstract
The 2010 cholera epidemic in Haiti was thought to have ended in 2019, and the Prime Minister of Haiti declared the country cholera-free in February 2022. On September 25, 2022, cholera cases were again identified in Port-auPrince. We compared genomic data from 42 clinical Vibrio cholerae strains from 2022 with data from 327 other strains from Haiti and 1,824 strains collected worldwide. The 2022 isolates were homogeneous and closely related to clinical and environmental strains circulating in Haiti during 2012–2019. Bayesian hypothesis testing indicated that the 2022 clinical isolates shared their most recent common ancestor with an environmental lineage circulating in Haiti in July 2018. Our findings strongly suggest that toxigenic V. cholerae O1 can persist for years in aquatic environmental reservoirs and ignite new outbreaks. These results highlight the urgent need for improved public health infrastructure and possible periodic vaccination campaigns to maintain population immunity against V. cholerae. [ABSTRACT FROM AUTHOR]