학술논문
Spirocyclic Iodonium Ylides for Fluorine‐18 Radiolabeling of Non‐Activated Arenes: From Concept to Clinical Research.
Document Type
Article
Source
Subject
*RADIOLABELING
*RADIOACTIVE tracers
*POSITRON emission tomography
*MEDICAL research
*YLIDES
*DRUG discovery
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Language
ISSN
1527-8999
Abstract
Positron emission tomography (PET) is a powerful imaging tool for drug discovery, clinical diagnosis, and monitoring of disease progression. Fluorine‐18 is the most common radionuclide used for PET, but advances in radiotracer development have been limited by the historical lack of methodologies and precursors amenable to radiolabeling with fluorine‐18. Radiolabeling of electron‐rich (hetero)aromatic rings remains a long‐standing challenge in the production of PET radiopharmaceuticals. In this personal account, we discuss the history of spirocyclic iodonium ylide precursors, from inception to applications in clinical research, for the incorporation of fluorine‐18 into complex non‐activated (hetero)aromatic rings. [ABSTRACT FROM AUTHOR]