부산대학교 도서관

Background: Men who have sex with men (MSM) are at high risk for oral human papillomavirus (HPV infection). There are no specific screening guidelines to facilitate the identification of people at risk for oral HPV infection. We aimed to estimate the prevalence of oral high‐risk HPV and create a risk score to identify MSM at higher risk for prevalent oral HPV. Methods: We collected baseline data from a clinical trial from a subsample of 500 MSM attending sexually transmitted disease treatment clinics; they provided an oral gargle sample for high‐risk HPV detection. We calculated oral high‐risk HPV prevalence and 95% confidence intervals (CIs), used a logistic regression model to identify factors associated with high‐risk HPV infection, and created a risk score. Results: The prevalence of any oral high‐risk HPV among MSM was 11.1% (95% CI: 8.6–14.2), with a higher prevalence observed among men living with HIV (14.8%). Factors independently associated with oral high‐risk HPV were age ≥40 years (OR = 2.71, 95% CI: 1.28–5.73 compared to <40 years), being HIV‐positive with CD4 count 200–499 (OR = 2.76, 95% CI: 1.34–5.65 compared to HIV‐negative), and recent recreational use of vasodilators (poppers/sildenafil) (OR = 2.02, 95% CI: 1.02–2.97). The risk score had good discriminatory power (AUC = 0.70, 95% CI: 0.63–0.77). Conclusions: MSM have specific predictors for prevalent oral high‐risk HPV, and a risk score could be used by clinicians to target men with vaccine recommendations and counseling, and identify those who could benefit from primary interventions given the available resources, or for referral to dental services for follow‐up when available. [ABSTRACT FROM AUTHOR]