학술논문
Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts.
Document Type
Article
Author
Yang, Chaojie; Veenstra, Jenna; Bartz, Traci M.; Pahl, Matthew C.; Hallmark, Brian; Chen, Yii-Der Ida; Westra, Jason; Steffen, Lyn M.; Brown, Christopher D.; Siscovick, David; Tsai, Michael Y.; Wood, Alexis C.; Rich, Stephen S.; Smith, Caren E.; O'Connor, Timothy D.; Mozaffarian, Dariush; Grant, Struan F. A.; Chilton, Floyd H.; Tintle, Nathan L.; Lemaitre, Rozenn N.
Source
Subject
*UNSATURATED fatty acids
*HISPANIC Americans
*GENOME-wide association studies
*OMEGA-6 fatty acids
*AFRICAN Americans
*LOCUS (Genetics)
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Language
ISSN
2399-3642
Abstract
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented strong genetic signals in/near the FADS locus on chromosome 11. We performed a GWAS of four n-3 and four n-6 PUFAs in Hispanic American (n = 1454) and African American (n = 2278) participants from three CHARGE cohorts. Applying a genome-wide significance threshold of P < 5 × 10−8, we confirmed association of the FADS signal and found evidence of two additional signals (in DAGLA and BEST1) within 200 kb of the originally reported FADS signal. Outside of the FADS region, we identified novel signals for arachidonic acid (AA) in Hispanic Americans located in/near genes including TMX2, SLC29A2, ANKRD13D and POLD4, and spanning a > 9 Mb region on chromosome 11 (57.5 Mb ~ 67.1 Mb). Among these novel signals, we found associations unique to Hispanic Americans, including rs28364240, a POLD4 missense variant for AA that is common in CHARGE Hispanic Americans but absent in other race/ancestry groups. Our study sheds light on the genetics of PUFAs and the value of investigating complex trait genetics across diverse ancestry populations. A genome-wide association study highlights the shared or unique genetic etiology of polyunsaturated fatty acids across diverse ancestry groups. [ABSTRACT FROM AUTHOR]