부산대학교 도서관

Aging and diseases such as cancer, peripheral artery disease (PAD) are associated with skeletal muscle inflammation, oxidative stress, increased senescense, altered muscle metabolism; and mitochondrial dysfunction [1-3]. Many of the biological changes in calf skeletal muscle have been associated with functional impairment and mobility loss [2]. We will discuss several recent studies which show that specific genes, miRNA, and biological pathways in skeletal muscle are tightly associated with functional performance in aging and clinical progression of PAD [3-6]. We found damage in the genes encoding polypeptides for the electron transport chain (ETC) in skeletal muscle was associated with walking performance in people with and without PAD [5]. We also found marked changes in cellular pathways in subjects with peripheral artery disease progression in specific genes and pathways involve in cellular senescense, inflammation and muscle contraction. Identifying what biological pathways are specifically associated with impaired skeletal muscle function may lead to new effective strategies that can reverse muscle dysfunction and in turn, can improve mobility. [ABSTRACT FROM AUTHOR]