부산대학교 도서관

Background: In this study, we wanted to evaluate the prevalence of insulin resistance in ischemic stroke (IS) by using a homeostasis model assessment for insulin resistance (IR). Methods: This was a hospital-based cross-sectional analytical study conducted among 100 patients who presented with acute ischemic stroke to the Department of General Medicine and Neurology, Sriram Chandra Bhanja Medical College & Hospital (SCBMCH), Cuttack, Odisha from September 2020 to August 2021. The study was conducted after obtaining clearance from the institutional ethics committee (IEC) and written informed consent from the study participants. Results: The range of FBS, PPBS, Fasting Plasma Insulin (FPI) and HbA1c in the study population was 77-164, 119-240, 4.2-12.9 and 4.3-7.1 respectively. High prevalence of Abnormal Glucose Metabolism (AGM) expressed as Impaired Glucose tolerance (IGT) and Diabetes mellitus (DM) was observed in patients with ischemic stroke (60%), out of which 38 with IGT and 22 with DM. The mean systolic and diastolic blood pressure in the study population was expressed in mean ± SD in which 73 (73%) cases were hypertensive while 27 (27%) were not hypertensive. The distribution of cases according to the presence of dyslipidaemia, history of smoking and presence of atrial fibrillation (AF) on ECG was 46 (46%), 21 (21%) and 11 (11%) respectively. The distribution of subtypes of ischemic stroke was according to the presence of AF on ECG. Only patients with cardio-embolic (CE) stroke showed AF on ECG with a statistically significant difference between the three of the Atherothrombotic infarct (ATI), Cardio-embolic (CE), Lacunar Infarct (LI) subgroups (p < 0.001). Hypertension, dyslipidaemia, and smoking were positively correlated with Insulin Resistance with p-value <0.01, <0.01 and 0.012 respectively. Conclusion: The frequency of ischemic stroke is more among older individuals (age > 55 years), suggesting that age is an independent risk factor for stroke. Hypertension and dyslipidaemia are the two most common modifiable risk factors for ischemic stroke, particularly in patients with atherothrombotic and lacunar infarction. Insulin resistance and abnormal glucose metabolism are common in acute ischemic stroke patients with no history of diabetes. IGT and Insulin resistance correlated significantly with pathogenic factors underlying the development of ischemic stroke. Insulin resistance can modify and influence the role of modifiable risk factors in patients with ischemic stroke. [ABSTRACT FROM AUTHOR]