학술논문
Nonsteroidal anti-inflammatory drugs sensitize epithelial cells to Clostridioides difficile toxin-mediated mitochondrial damage.
Document Type
Article
Author
Source
Subject
*CLOSTRIDIOIDES difficile
*ANTI-inflammatory agents
*EPITHELIAL cells
*TOXINS
*MITOCHONDRIA
*REVERSE transcriptase
*
*
*
*
*
Language
ISSN
2375-2548
Abstract
The article offers information on how nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate Clostridioides difficile infection (CDI) by disrupting colonic epithelial cells and sensitizing them to C. difficile toxin-mediated damage, independent of their usual role of inhibiting cyclooxygenase (COX) enzymes. The study demonstrates that NSAIDs and C. difficile toxins target the mitochondria of colonic epithelial cells, leading to increased damage and inflammation during CDI.