부산대학교 도서관

Background: The presence of anticancer drugs in water sources has become critical in recent years. Anticancer drugs are used in controlled amounts and conditions in medical centers. Cancerostatic platinum complexes (CPC) like cisplatin, carboplatin, and oxaliplatin are used in oncology centers to treat many cancers. Objectives: We determined the environmental risk of these compounds in municipal wastewater effluent of Qom, Iran. Methods: The LC-MS/MS technique quantified platinum complex drugs in wastewater effluent. Based on the blank laborator method, the limit of detection (LOD) was determined as 0.009 μg/L, 0.013 μg/L, and 0.017 μg/L for oxaliplatin, carboplatin, and cisplatin, respectively. Results: The cisplatin, carboplatin, and oxaliplatin concentrations in wastewater effluent were 0.19 ± 0.098, 0.22 ± 0.094, and 0.12 ± 0.059 μg/L, respectively. Ecological risk assessment results indicated that RQsw for cisplatin, carboplatin, and oxaliplatin was 0.017, 0.013, and 0.02, respectively, showing that the platinum complex drugs had insignificant ecological exposure risk. Furthermore, WQsw was estimated at < 1. Conclusions: Managing cytotoxic waste from hospital oncology wards is vital for environmental pollution control. The use of other methods to remove these compounds, such as advanced oxidation processes and membrane systems, is inevitable.