학술논문

Patient perspectives on risk-reducing salpingectomy with delayed oophorectomy for ovarian cancer risk-reduction: A systematic review of the literature.
Document Type
Article
Source
Gynecologic Oncology. Jun2023, Vol. 173, p106-113. 8p.
Subject
*SALPINGECTOMY
*PATIENTS' attitudes
*OVARIECTOMY
*OVARIAN cancer
*CANCER genetics
*PATIENT preferences
*SURGICAL complications
Language
ISSN
0090-8258
Abstract
Increasing evidence suggests the fallopian tube as the site of origin of BRCA1/2-associated high-grade ovarian cancers. Several ongoing trials are evaluating salpingectomy with delayed oophorectomy (RRSDO) for ovarian cancer risk reduction and patients are beginning to ask their clinicians about this surgical option. This study sought to systematically review the available literature examining patient preferences regarding RRSDO and risk-reducing salpingo-oophorectomy (RRSO) to provide clinicians with an understanding of patient values, concerns, and priorities surrounding ovarian cancer risk-reducing surgery. We conducted a systematic review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO No.: CRD42023400690). We searched key electronic databases to identify studies evaluating acceptance and surgical decision-making regarding RRSO and RRSDO among patients with an increased risk of ovarian cancer. The search yielded 239 results, among which six publications met the systematic review inclusion criteria. Acceptance of RRSDO was evaluated in all studies and ranged from 34% to 71%. Factors positively impacting patients' acceptance of RRSDO included: avoidance of surgical menopause, preservation of fertility, concerns about sexual dysfunction, family history of breast cancer, and avoidance of hormone replacement therapy. Factors limiting this acceptance reported by patients included concerns regarding oncologic safety, surgical timing, and surgical complications. To date, few studies have explored patient perspectives surrounding RRSDO. Collectively, the limited data available indicate a high level of acceptance among BRCA1/2 carriers, and provides insight regarding both facilitating and limiting factors associated with patient preferences to better equip clinicians in the counseling and support of their patients. • This systematic review explores patient preferences related to risk-reducing salpingectomy with delayed oophorectomy(RRSDO). • The current literature suggests acceptance rates of RRSDO range between 34 and 71%. • Factors that facilitate RRSDO acceptance include avoiding surgical menopause, preservation of fertility and sexual function. • Limiting factors of RRSDO acceptance are concerns about oncologic safety, surgical complications, and breast cancer history. • More inclusive trials in cancer genetics are needed to move towards improved health equity in this field. [ABSTRACT FROM AUTHOR]