학술논문
Multiscale network analysis identifies potential receptors for SARS‐CoV‐2 and reveals their tissue‐specific and age‐dependent expression.
Document Type
Article
Author
Source
Subject
*GENE expression
*COVID-19
*SARS-CoV-2
*GENE regulatory networks
*CELL receptors
*CYTOKINE receptors
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Language
ISSN
0014-5793
Abstract
The coronavirus disease 2019 (COVID‐19) pandemic has affected tens of millions of individuals and caused hundreds of thousands of deaths worldwide. Here, we present a comprehensive, multiscale network analysis of the transcriptional response to the virus. In particular, we focused on key regulators, cell receptors, and host processes that were hijacked by the virus for its advantage. ACE2‐controlled processes involved CD300e (a TYROBP receptor) as a key regulator and the activation of IL‐2 pro‐inflammatory cytokine signaling. We further investigated the age dependency of such receptors in different tissues. In summary, this study provides novel insights into the gene regulatory organization during the SARS‐CoV‐2 infection and the tissue‐specific, age‐dependent expression of the cell receptors involved in COVID‐19. [ABSTRACT FROM AUTHOR]