부산대학교 도서관

• American diabetes A. Diagnosis and classification of diabetes Mellitus. Diabetes Care. 2010;33(Suppl 1):S62-S9. • Witte MB, Barbul A. Role of nitric oxide in wound repair. The American Journal of Surgery. 2002;183(4):406–12. • Kim KH, Schaller DJ. Nitroglycerin. 2018. Diabetes mellitus (DM) is known as a metabolic disorder characterized by high and permanent abnormal blood glucose levels (hyperglycemia). In this domain, one of the complications of DM is a significant delay in wound healing and nitric oxide (NO) plays numerous important roles in healing normal wounds. Thus, the purpose of this study was to increase NO levels in the wound area using topical glyceryl trinitrate (GTN) in order to improve the wound healing process in diabetic Rats. This experimental animal study was performed on a total number of 78 male Wistar albino rats. The rats were divided into 6 groups. Thirty-nine rats were rendered diabetic with streptozotocin (STZ). After that, a circular ulcer was made in the center of the hard palate using punch biopsy. Topical GTN was also applied on the wound area one day after biopsy. Subsequently, the rats were sacrificed on the 7th and 14th days. Histopathologic evaluation criteria in this study included measurement of maximum epithelium, papilla, and lamina propria thickness; mean number of blood vessels and fibroblasts, as well as inflammation rate. Furthermore, the data were analyzed using the SPSS software. The findings revealed that the use of topical GTN in diabetic rats had a positive effect on the number of vessels and fibroblasts as well as modulated inflammation. The results also demonstrated that thickness had resulted in accelerations in groups wherein GTN had been applied. However, no significant results were found in the evaluation of epithelium and papilla thickness. Use of GTN on mucosal ulcers could lead to a significant increase in the number of blood vessels and fibroblasts as well as regulation of inflammation, which could have significant impacts on wound healing process in diabetic rat. [ABSTRACT FROM AUTHOR]