학술논문
Association of Severe Hypercholesterolemia and Familial Hypercholesterolemia Genotype With Risk of Coronary Heart Disease.
Document Type
Article
Author
Zhang, Yiyi; Dron, Jacqueline S.; Bellows, Brandon K.; Khera, Amit V.; Liu, Junxiu; Balte, Pallavi P.; Oelsner, Elizabeth C.; Amr, Sami Samir; Lebo, Matthew S.; Nagy, Anna; Peloso, Gina M.; Natarajan, Pradeep; Rotter, Jerome I.; Willer, Cristen; Boerwinkle, Eric; Ballantyne, Christie M.; Lutsey, Pamela L.; Fornage, Myriam; Lloyd-Jones, Donald M.; Hou, Lifang
Source
Subject
*CORONARY disease
*GENETIC testing
*HDL cholesterol
*GENOTYPES
*
*
*
Language
ISSN
0009-7322
Abstract
Footnotes 1 Nonstandard Abbreviations and Acronyms CHD coronary heart disease FH familial hypercholesterolemia LDL-C low-density lipoprotein cholesterol 2 S.D. de Ferranti and A.E. Moran contributed equally. Keywords: cardiovascular disease; familial hypercholesterolemia; genotype; low-density lipoprotein cholesterol; phenotype EN cardiovascular disease familial hypercholesterolemia genotype low-density lipoprotein cholesterol phenotype 1556 1559 4 05/15/23 20230516 NES 230516 Familial hypercholesterolemia (FH) is a genetic disorder characterized by markedly elevated low-density lipoprotein cholesterol (LDL-C) from birth that often causes premature coronary heart disease (CHD).[1] FH can be diagnosed with established clinical criteria such as the Dutch Lipid Clinic Network criteria with or without genetic testing.[1] This study aimed to quantify the risks for incident CHD events associated with severe hypercholesterolemia (LDL-C >=190 mg/dL) with or without an FH genotype. APOB indicates apolipoprotein B; CHD, coronary heart disease; FH, familial hypercholesterolemia; LDL-C, low-density lipoprotein cholesterol; LDLR, low-density lipoprotein receptor; and PCSK9: proprotein convertase subtilisin/kexin type 9. [Extracted from the article]