학술논문
Ancient DNA suggests anaemia and low bone mineral density as the cause for porotic hyperostosis in ancient individuals.
Document Type
Article
Author
Source
Subject
*BONE density
*FOSSIL DNA
*EXOSTOSIS
*DISEASE risk factors
*ANEMIA
*VITAMIN D receptors
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Language
ISSN
2045-2322
Abstract
Porotic hyperostosis (PH) is a disease that had high prevalence during the Neolithic. Several hypotheses have been suggested to explain the origin of the disease, such as an iron deficiency diet, low B12 intake, malaria caused by Plasmodium spp., low haemoglobin levels or low vitamin D levels. None of these hypotheses have been tested genetically. Here, I calculated different genetic scores to test each hypothesis. Additionally, I calculated a genetic score of bone mineral density as it is a phenotype that seems to be selected in ancient Europeans. I apply these genetic scores on 80 ancient samples, 33 with diagnosed PH. The results seem to suggest anaemia and low bone mineral density as the main cause for this disease. Additionally, Neolithic individuals show the lowest genetic risk score for bone mineral density of all other periods tested here, which may explain the highest prevalence of the porotic hyperostosis during this age. [ABSTRACT FROM AUTHOR]