학술논문

In vitromodels for oral malodor.
Document Type
Article
Source
Oral Diseases. Jan2005 Supplement 1, Vol. 11, p14-23. 10p.
Subject
*BAD breath
*ORAL diseases
*RESPIRATORY diseases
*TONGUE
*ORAL medicine
Language
ISSN
1354-523X
Abstract
A model is a representation of some real phenomena and contains aspects or elements of the real system to be modeled. The model reflects (or duplicates) the type of behavior (or mechanisms) seen in the real system. The main characteristic of any model is the mapping of elements or parameters found in the system being studied (e.g. tongue dorsum biofilmin situ) on to the model being devised (e.g. laboratory perfusion biofilm). Such parameters include correct physico-chemical (abiotic) conditions as well as biotic conditions that occur in both model and reality. The main purpose of a model is to provide information that better explains the processes observed or thought to occur in the real system. Such models can be abstract (mental, conceptual, theoretical, mathematical or computational) or‘physical’, e.g. in the form of a real disaggregatedin vitrosystem or laboratory model. A wide range of different model systems have been used in oral biofilm research. These will be briefly reviewed with special emphasis on those models that have contributed most to knowledge in breath odor research. The different model systems used in breath odor research are compared. Finally, the requirements for developing an overall‘bad breath model’ from considering the processes as a whole (real oral cavity, substrates in saliva, biotransformation by tongue microflora, odor gases in the breath) and extending this to the detection of malodor by the human nose will be outlined and discussed. [ABSTRACT FROM AUTHOR]