학술논문
A new role of TRPM8 in circadian rhythm and molecular clock.
Document Type
Article
Source
Subject
*MOLECULAR clock
*CIRCADIAN rhythms
*TRP channels
*PERIPHERAL nervous system
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Language
ISSN
1748-1708
Abstract
Injection of the fluorescent anterograde tracer cholera toxin subunit B (CTB-594) into both eyes in two TRPM8 reporter lines indicates the existence of ipRGCs expressing TRPM8 and projecting to the SCN (Figure 1). The cold-sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature. Over the past decades, studies of the TRPM8 channel, a non-selective cation channel, have provided much insight into the fundamental mechanisms of sensory neuron function that lead to the detection of cold sensors. [Extracted from the article]