학술논문
Maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age: a prospective cohort study.
Document Type
Article
Author
Miyake, Kunio; Kushima, Megumi; Shinohara, Ryoji; Horiuchi, Sayaka; Otawa, Sanae; Akiyama, Yuka; Ooka, Tadao; Kojima, Reiji; Yokomichi, Hiroshi; Yamagata, Zentaro; The Japan Environment and Children's Study Group; Kamijima, Michihiro; Yamazaki, Shin; Ohya, Yukihiro; Kishi, Reiko; Yaegashi, Nobuo; Hashimoto, Koichi; Mori, Chisato; Ito, Shuichi; Inadera, Hidekuni
Source
Subject
*ASTHMA
*SMOKING statistics
*SMOKING
*ASTHMA in children
*LOGISTIC regression analysis
*PREGNANCY
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Language
ISSN
2045-2322
Abstract
The association between maternal pre-pregnancy smoking status and asthma risk is unclear. This study aimed to investigate the association between pre- and post-pregnancy maternal smoking status and bronchial asthma at 3 years of age in a large birth cohort. Data of 75,411 mother–child pairs from the Japan Environment and Children's Study (JECS) were analysed using multivariate logistic regression analysis. Overall, 7.2% of the children had bronchial asthma. The maternal smoking status before childbirth was as follows: Never = 60.0%, Quit before recognising current pregnancy = 24.1%, Quit after finding out about current pregnancy = 12.3%, and Still smoking = 3.6%. Children of mothers who sustained smoking during pregnancy had an increased risk of bronchial asthma at 3 years of age even after adjusting for pre- and postnatal covariates (adjusted odds ratio [aOR] 1.34, 95% confidence interval [CI] 1.15–1.56). Children of mothers who quit before (aOR 1.09, 95% CI 1.02–1.18) or after (aOR 1.11, 95% CI 1.01–1.23) recognising the current pregnancy had an increased risk of bronchial asthma at 3 years of age. Maternal smoking throughout pregnancy and smoking exposure pre-pregnancy or in early pregnancy increases the risk of bronchial asthma in children. [ABSTRACT FROM AUTHOR]