학술논문
Long-Term Exposure to Transportation Noise and Ischemic Heart Disease: A Pooled Analysis of Nine Scandinavian Cohorts.
Document Type
Article
Author
Pyko, Andrei; Roswall, Nina; Ögren, Mikael; Oudin, Anna; Rosengren, Annika; Eriksson, Charlotta; Segersson, David; Rizzuto, Debora; Andersson, Eva M.; Aasvang, Gunn Marit; Engström, Gunnar; Gudjonsdottir, Hrafnhildur; Jørgensen, Jeanette T.; Selander, Jenny; Christensen, Jesper H.; Brandt, Jørgen; Leander, Karin; Overvad, Kim; Eneroth, Kristina; Mattisson, Kristoffer
Source
Subject
*MYOCARDIAL infarction risk factors
*AIR pollution
*LIFESTYLES
*STATISTICS
*CONFIDENCE intervals
*NOISE
*MYOCARDIAL ischemia
*AGE distribution
*TIME
*ANGINA pectoris
*POPULATION geography
*RISK assessment
*SOCIOECONOMIC factors
*SEX distribution
*INCOME
*PHYSICAL activity
*RESEARCH funding
*DESCRIPTIVE statistics
*RAILROADS
*AIRPLANES
*SCANDINAVIANS
*MARITAL status
*SMOKING
*BODY mass index
*SENSITIVITY & specificity (Statistics)
*DATA analysis
*DATA analysis software
*TRANSPORTATION
*ENVIRONMENTAL exposure
*DOSE-response relationship in biochemistry
*NORDIC people
*PROPORTIONAL hazards models
*LONGITUDINAL method
*EDUCATIONAL attainment
*DISEASE risk factors
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Language
ISSN
0091-6765
Abstract
BACKGROUND: Transportation noise may induce cardiovascular disease, but the public health implications are unclear. OBJECTIVES: The study aimed to assess exposure–response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes. METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were calculated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors. RESULTS: A total of 22,459 incident cases of IHD were identified during follow-up from national patient and mortality registers, including 7,682 cases of myocardial infarction. The adjusted HR for IHD was 1.03 [95% confidence interval (CI) 1.00, 1.05] per 10 dB Lden for both road and railway noise exposure during 5 y prior to the event. Higher risks were indicated for IHD excluding angina pectoris cases, with HRs of 1.06 (95% CI: 1.03, 1.08) and 1.05 (95% CI: 1.01, 1.08) per 10 dB Lden for road and railway noise, respectively. Corresponding HRs for myocardial infarction were 1.02 (95% CI: 0.99, 1.05) and 1.04 (95% CI: 0.99, 1.08). Increased risks were observed for aircraft noise but without clear exposure-response relations. A threshold at around 55 dB Lden was suggested in the exposure-response relation for road traffic noise and IHD. DISCUSSION: Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries. [ABSTRACT FROM AUTHOR]