학술논문
PHGDH and cancer: new job for an old enzyme!
Document Type
Article
Author
Source
Subject
*ENZYMES
*LIVER cancer
*ENERGY metabolism
*CANCER invasiveness
*CANCER cells
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Language
ISSN
0261-4189
Abstract
How do cancer cells bolster their energy metabolism under conditions of stress? Recent work by Shu et al (2022) unveils a novel, non‐canonical function of the de novo serine synthesis pathway enzyme phosphoglycerate dehydrogenase (PHGDH) as a regulator of mitochondrial translation and tumor progression in liver cancer. [ABSTRACT FROM AUTHOR]