부산대학교 도서관

Background: Gait deficits in people with Parkinson's disease (PD) are triggered by circumstances requiring gait adaptation. The effects of gait adaptation training on a split‐belt treadmill (SBT) are unknown in PD. Objective: We investigated the effects of repeated SBT versus tied‐belt treadmill (TBT) training on retention and automaticity of gait adaptation and its transfer to over‐ground walking and turning. Methods: We recruited 52 individuals with PD, of whom 22 were freezers, in a multi‐center randomized single‐blind controlled study. Training consisted of 4 weeks of supervised treadmill training delivered three times per week. Tests were conducted pre‐ and post‐training and at 4‐weeks follow‐up. Turning (primary outcome) and gait were assessed over‐ground and during a gait adaptation protocol on the treadmill. All tasks were performed with and without a cognitive task. Results: We found that SBT‐training improved gait adaptation with moderate to large effects sizes (P < 0.02) compared to TBT, effects that were sustained at follow‐up and during dual tasking. However, better gait adaptation did not transfer to over‐ground turning speed. In both SBT‐ and TBT‐arms, over‐ground walking and Movement Disorder Society‐Unified Parkinson's Disease Rating Scale III (MDS‐UPDRS‐III scores were improved, the latter of which reached clinically meaningful effects in the SBT‐group only. No impact was found on freezing of gait. Conclusion: People with PD are able to learn and retain the ability to overcome asymmetric gait‐speed perturbations on a treadmill remarkably well, but seem unable to generalize these skills to asymmetric gait off‐treadmill. Future study is warranted into gait adaptation training to boost the transfer of complex walking skills. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]