부산대학교 도서관

We determined that the Tp53 stain is wild-type and the Smad4 stain is intact in both regions. gl Our identification of a microscopic, intraparenchymal pancreatic cancer metastasis highlights one mechanism for tumour recurrence in the remnant pancreas after apparently curative surgery. Using CODA, a technique for three-dimensional reconstruction of large tissues, Kiemen et al. report observation of a microscopic focus of pancreatic cancer found in the vasculature of grossly normal human pancreas tissue resected adjacent to a large tumour. Gain of tumour protein I Tp53 i is found in approximately 85% of pancreatic cancers, while loss of I Smad4 i is found in approximately 55% of pancreatic cancers.[5] We found that both foci had wild-type labelling for I Tp53 i and intact I Smad4 i expression (Figure 2). [Extracted from the article]