학술논문
SFRP1 in Regulation of Skin Cancer and Cancer Stem Cells Associated through Noncanonical WNT Signaling.
Document Type
Article
Author
Source
Subject
*CANCER stem cells
*WNT signal transduction
*SKIN cancer
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Language
ISSN
0971-5851
Abstract
SFRP1, a Wnt-inhibitor, is downregulated in various human cancers; earlier study observed inverse correlation between SFRP1 and SOX2 in human oral and breast cancers. Expression profiling of CSCs showed upregulation of genes involved in EMT (Vimentin, TWIST1), stemness marker SOX2, and noncanonical Wnt signaling that suggest an enhanced tumorigenic potential of CSCs. We observed the upregulation in protein expression of noncanonical Wnt signaling cascade (Rac1-Dvl2-JNK-c-JUN-SOX2). [Extracted from the article]