학술논문
The value of a two-armed Bayesian response adaptive randomization trial.
Document Type
Article
Author
Source
Subject
*DOCOSAHEXAENOIC acid
*BIRTH rate
*COVID-19 pandemic
*
*
Language
ISSN
1054-3406
Abstract
We investigate the value of a two-armed Bayesian response adaptive randomization (RAR) design to investigate early preterm birth rates of high versus low dose of docosahexaenoic acid during pregnancy. Unexpectedly, the COVID-19 pandemic forced recruitment to pause at 1100 participants rather than the planned 1355. The difference in power between number of participants at the pause and planned was 87% and 90% respectively. We decided to stop the study. This paper describes how the RAR was used to execute the study. The value of RAR in two-armed studies is quite high and their use in the future is promising. [ABSTRACT FROM AUTHOR]