부산대학교 도서관

Our study hypothesizes that pediatric sickle cell disease will lead to increased renal clearance due to glomerular hyperfiltration that will require higher doses of vancomycin to reach therapeutic levels when compared to the general pediatric population. This in turn can significantly increase the risk of mortality, as sickle cell patients may be given inadequate doses with the goal of achieving therapeutic vancomycin drug concentrations in the setting of life-threatening infections. [Extracted from the article]