학술논문
SIRT6: therapeutic target for nonalcoholic fatty liver disease.
Document Type
Article
Author
Source
Subject
*NON-alcoholic fatty liver disease
*FATTY acid oxidation
*
Language
ISSN
1043-2760
Abstract
Recently, Hou et al. shifted the research focus from the function of nuclear sirtuin (SIRT)6 to that of cytoplasmic SIRT6, which deacetylates and activates long-chain acyl-CoA synthase 5 (ACSL5). Their findings provide mechanistic insight into the role of cytoplasmic SIRT6 in fatty acid oxidation, acting as a therapeutic target for combating nonalcoholic fatty liver disease (NAFLD). [ABSTRACT FROM AUTHOR]