학술논문
Lack of direct association between oral mucosal lesions and SARS-CoV- 2 in a cohort of patients hospitalised with COVID-19.
Document Type
Article
Author
Schwab, Gabriela; Palmieri, Michelle; Zerbinati, Rodrigo M.; Sarmento, Dmitry J. S.; Reis, Thais; Ortega, Karem L.; Kano, Italo T.; Caixeta, Rafael A. V.; Hasséus, Bengt; Sapkota, Dipak; Junges, Roger; Giannecchini, Simone; Costa, André L. F.; Jales, Sumatra M. C. P.; Lindoso, José A. L.; Gallo, Camila Barros; Braz-Silva, Paulo H.
Source
Subject
*COVID-19
*OPPORTUNISTIC infections
*ORGANS (Anatomy)
*ANGIOTENSIN converting enzyme
*ORAL manifestations of general diseases
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Language
ISSN
2000-2297
Abstract
COVID-19 is a disease affecting various human organs and systems, in which the virus seeks to interact with angiotensin-converting enzyme 2 receptors. These receptors are present in the oral cavity, but the direct relationship between such an interaction and possible oral manifestations of COVID-19 is still unclear. The present study evaluated oral manifestations in a cohort of COVID-19 patients during the period of hospitalisation. In total, 154 patients presenting moderate-to-severe forms of COVID-19 had their oral mucosa examined twice a week until the final outcome, either discharge or death. The oral alterations observed in the patients were grouped into Group 1 (pre-existing conditions and opportunistic oral lesions) and Group 2 (oral mucosal changes related to hospitalization). Oral lesions found in the patients of Group 1 are not suggestive of SARS-CoV-2 infection as they are mainly caused by opportunistic infections. On the other hand, oral alterations found in the patients of Group 2 were statistically (P < 0.001) related to intubation and longer period of hospitalisation. It is unlikely that ulcerative lesions in the oral cavity are a direct manifestation of SARS-CoV-2 or a marker of COVID-19 progression. [ABSTRACT FROM AUTHOR]