학술논문
Aptamer Proteomics for Biomarker Discovery in Heart Failure With Reduced Ejection Fraction.
Document Type
Article
Author
Zhang, Luqing; Cunningham, Jonathan W.; Claggett, Brian L.; Jacob, Jaison; Mendelson, Michael M.; Serrano-Fernandez, Pablo; Kaiser, Sergio; Yates, Denise P.; Healey, Margaret; Chen, Chien-Wei; Turner, Gordon M.; Patel-Murray, Natasha L.; Zhao, Faye; Beste, Michael T.; Laramie, Jason M.; Abraham, William T.; Jhund, Pardeep S.; Kober, Lars; Packer, Milton; Rouleau, Jean
Source
Subject
Language
ISSN
0009-7322
Abstract
Keywords: biomarkers; heart failure; proteomics; SVEP1 protein, human EN biomarkers heart failure proteomics SVEP1 protein, human 1411 1414 4 11/03/22 20221101 NES 221101 Systematically characterizing associations between circulating proteins and risk for hospitalization and death may identify novel biological pathways and improve risk prediction in heart failure (HF). Baseline protein levels associated with the trial primary end point of HF hospitalization or cardiovascular death were identified in the ATMOSPHERE discovery cohort by Cox regression (false discovery rate <0.05), and replicated in PARADIGM-HF (Bonferroni-corrected I P i <0.05). In minimally adjusted models, 377 proteins were associated with risk of HF hospitalization or cardiovascular death (false discovery rate <0.05) in the discovery cohort (ATMOSPHERE), and of these, 167 were replicated in PARADIGM-HF (Bonferroni-adjusted I P i <0.05). [Extracted from the article]