부산대학교 도서관

Combination immunotherapy with nivolumab and ipilimumab is an effective therapy in the treatment of metastatic melanoma, however, its benefit in older patients is unclear. A multicentre retrospective study was performed to compare the efficacy and toxicity of combination immunotherapy in metastatic melanoma in patients ≥65 years versus <65 years, and complications of steroids used to manage toxicity. One hundred and thirty‐nine patients were included with 52 patients ≥65 years (median age: 70; range: 65–83) and 87 patients <65 years (median age: 52; range: 22–64). Median overall survival was similar in patients ≥65 years versus <65 years (14.9 vs. 17.3 months p =.58). Median progression‐free survival was also similar in both groups (7.1 vs. 6.9 months p =.79), as was overall response rate (48.1% vs. 44.8% p =.73). Age was not associated with a difference in overall survival on multivariate analysis. There was similar rates of Grade 3 or higher adverse events in patients ≥65 years versus <65 years (50% vs. 49% p = 1.0) and discontinuation rates secondary to toxicity (55.8% vs. 56% p = 1.0). Median duration of steroids used to treat adverse events was similar (11 vs. 12 weeks p =.46). Complications of steroids requiring inpatient admission was numerically higher in the older patients (41.3% vs. 20.4% p =.07). Patients ≥65 years received similar benefit from combination immunotherapy in comparison to their younger counterparts with similar toxicity. [ABSTRACT FROM AUTHOR]