학술논문
Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children.
Document Type
Article
Author
Source
Subject
*BLOCKING antibodies
*GASTROENTERITIS
*STATISTICS
*DIARRHEA
*ONE-way analysis of variance
*MANN Whitney U Test
*NOROVIRUS diseases
*GENES
*GENOTYPES
*IMMUNITY
*DESCRIPTIVE statistics
*VIRAL antibodies
*RNA viruses
*DATA analysis
*LONGITUDINAL method
*CHILDREN
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Language
ISSN
2048-7193
Abstract
A birth cohort design was used to understand whether heterotypic ligand-blocking norovirus antibodies provide cross-protection within the GII genogroup. We found that almost one-half of children who experienced a norovirus GII episode had preexisting antibodies heterotypic to the infecting genotype; therefore, these antibodies did not provide cross-protection. [ABSTRACT FROM AUTHOR]