부산대학교 도서관

In recent decades, dengue has been expanding rapidly in the tropical cities. Even though environmental factors and landscape features profoundly impact dengue vector abundance and disease epidemiology, significant gaps exist in understanding the role of local environmental heterogeneity on dengue epidemiology in India. In this study, we assessed the role of remotely sensed climatic factors (rainfall, temperature and humidity) and landscape variables (land use pattern, vegetation and built up density) on dengue incidence (2012–2019) in Bhopal city, Central India. Dengue hotspots in the city were assessed through geographical information system based spatial statistics. Dengue incidence increased from 0.59 cases in 2012 to 9.11 cases in 2019 per 10,000 inhabitants, and wards located in Southern Bhopal were found to be dengue hotspots. Distributed lag non-linear model combined with quasi Poisson regression was used to assess the exposure-response association, relative risk (RR), and delayed effects of environmental factors on dengue incidence. The analysis revealed a non-linear relationship between meteorological variables and dengue cases. The model shows that the risk of dengue cases increases with increasing mean temperature, rainfall and absolute humidity. The highest RR of dengue cases (~2.0) was observed for absolute humidity ≥60 g/m3 with a 5–15 week lag. Rapid urbanization assessed by an increase in the built-up area (a 9.1% increase in 2020 compared to 2014) could also be a key factor driving dengue incidence in Bhopal city. The study sheds important insight into the synergistic effects of both the landscape and climatic factors on the transmission dynamics of dengue. Furthermore, the study provides key baseline information on the climatic variables that can be used in the micro-level dengue prediction models in Bhopal and other cities with similar climatic conditions. Author summary: Dengue, a viral disease transmitted by infected Aedes mosquitoes, is a major public health concern globally. In addition to its increased incidence in recent years, dengue is also spreading to new geographical regions. Local environmental factors are known to modify the mosquito vector density that directly impacts dengue virus transmission. Understanding the influence of environmental factors (meteorological conditions and landscape features) on dengue epidemiology in local settings is important for focused dengue intervention. Here, by utilizing dengue incidence and remotely sensed environmental data from 2012–2019, we have assessed the role of environmental factors in driving dengue virus transmission in the city of Bhopal in Central India. During the study period, a 14.5 fold increase in dengue incidence was observed in Bhopal city, which is way higher than the 2.3 fold increase reported at the national level. The risk of dengue virus transmission was higher with higher temperature and absolute humidity. An increase in built-up area, a proxy for urbanization, was found to be another predictor of increased dengue incidence in Bhopal. These findings can provide a stepping-stone for the development of dengue prediction models and the identification of dengue hotspots in order to improve vector control of this disease in cities with similar environmental conditions. [ABSTRACT FROM AUTHOR]