학술논문
Association between Toxoplasma gondii Infection and Nephrotic Syndrome Risk in Children: A Case-Control Study and Systematic Review.
Document Type
Journal Article
Author
Source
Subject
*PROTOZOA
*RESEARCH
*IMMUNOGLOBULINS
*NEPHROTIC syndrome
*RESEARCH methodology
*TOXOPLASMOSIS
*CASE-control method
*EVALUATION research
*COMPARATIVE studies
*ENZYME-linked immunosorbent assay
*EPIDEMIOLOGICAL research
*DISEASE complications
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Language
ISSN
0142-6338
Abstract
Some evidence suggests toxoplasmosis as an etiology of nephrotic syndrome (NS) in children; however, no observational study evaluated this relationship. In a case-control study, we enrolled 35 children with NS and 37 healthy children. All participants were examined for anti-Toxoplasma immunoglobulin G and M (IgG and IgM) antibodies using enzyme-linked immunosorbent assay. We also systematically reviewed the literature to assess this relationship. Prevalence of anti-Toxoplasma IgG was 17.4% and 13.5% in cases and controls, respectively, indicating a non-significant association (adjusted odds ratio, 1.22, 95% confidence interval, 0.35-4.41). No subjects were seropositive for IgM. In a systematic review, we found that acute toxoplasmosis can induce NS in some children and anti-Toxoplasma treatment is effective in the remission of NS in these cases. In pediatrics with NS, acute toxoplasmosis should be considered as a neglected causative factor. [ABSTRACT FROM AUTHOR]