부산대학교 도서관

Background: Androgenic alopecia (AGA) is a common hair loss disorder seen in both males and females and continues by presenting thinning and miniaturization because of androgens, genetics, extracellular matrix (ECM) protein destruction, and micro-inflammation. The most common treatments for AGA used in males are minoxidil and finasteride. These drugs have an effective role in the recovery and retardation of hair loss; however, there are different side effects and limitations to their efficacy. Materials and Methods: In this research, we compared the effectiveness of the Trust tonic's active complex, Capixyl, Procapil, and rosemary extract (CPR), and 2% minoxidil solution in reducing hair loss and stimulating hair growth. The study was conducted on two groups of male subjects with an average of 45 years for twenty-four weeks using 1 ml of each solution everyday in the morning and evening. Results: The results of this study revealed that the subjects treated with the Trust active complex, obtain significantly higher self-assessment (64% in the Trust tonic group and 36% in the minoxidil group) and the staff assessment scores of hair growth improvement in 60% and 30%, respectively, for the Trust tonic group and minoxidil group. Furthermore, the scores obtained by the photographic method also revealed a 57% and 8% improvement in hair growth in the patients who used the Trust complex and minoxidil, respectively. Conclusions: The active complex of the Trust tonic solution could be an effective alternative for minoxidil in the treatment of AGA. [ABSTRACT FROM AUTHOR]