학술논문

Neuroimmune interactions in health and disease.
Document Type
Article
Source
Seminars in Immunopathology. Sep2022, Vol. 44 Issue 5, p565-567. 3p.
Subject
*AUTOANTIBODIES
*MICROGLIA
*PATHOLOGY
*HUMAN biology
*ALZHEIMER'S disease
*T helper cells
*NEUROLOGICAL disorders
*B cells
Language
ISSN
1863-2297
Abstract
This article is a contribution to the special issue on: Neuroimmune Interactions in Health and Disease - Guest Editors: David Hafler & Lauren Sansing On our bookshelf is a monograph with a series of reviews from the 1950s edited by Marian Kies that provides a snapshot into the field of neuroinflammation some half a century ago. As a better understanding of relapsing clinical autoimmune demyelinating disease has been revealed, it has become clear that multiple sclerosis is a distinct disease from neuromyelitis optica (NMO) where autoantibodies reactive to a water channel protein aquaporin 4 (AQP4) is detected in patients that plays a key role in the disease's pathology. We highlight recent advances in the field of neuroinflammation that has undergone incredible expansion over the past decade as we have better recognized the role of inflammation in neurologic diseases focusing on neuroimmune interactions in health and disease. [Extracted from the article]