학술논문
Type I interferons during host–fungus interactions: Is antifungal immunity going viral?
Document Type
Article
Source
Subject
*TYPE I interferons
*INFLAMMATORY bowel diseases
*PULMONARY aspergillosis
*IMMUNITY
*MYCOSES
*VIRUS diseases
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Language
ISSN
1553-7366
Abstract
C. albicans causes specific enrichment of IFN-I responses, and genetic variations in the IFN-I pathway are linked to susceptibility to candidiasis and aspergillosis. Type I interferons (IFN-I) are crucial in antiviral host defense. Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-beta signaling. Type I interferons during host-fungus interactions: Is antifungal immunity going viral?. [Extracted from the article]