학술논문
The effect of Bacillus coagulans Unique IS-2 supplementation on plasma amino acid levels and muscle strength in resistance trained males consuming whey protein: a double-blind, placebo-controlled study.
Document Type
Article
Author
Source
Subject
*AMINO acid analysis
*RESISTANCE training
*LACTOSE
*BODY composition
*BIOMARKERS
*INTERLEUKINS
*C-reactive protein
*BRANCHED chain amino acids
*ANALYSIS of variance
*CONFIDENCE intervals
*UREA
*BLOOD plasma
*OXYGEN consumption
*SERUM
*IRON
*INFLAMMATION
*SALIVA
*BACILLUS (Bacteria)
*ISOLEUCINE
*MUSCULAR hypertrophy
*BLOOD collection
*CREATINE kinase
*IRON in the body
*ANTIOXIDANTS
*FISHER exact test
*MANN Whitney U Test
*RESPIRATORY infections
*DIETARY supplements
*PROBIOTICS
*TREATMENT effectiveness
*RANDOMIZED controlled trials
*PRE-tests & post-tests
*INTERFERONS
*T-test (Statistics)
*INTESTINAL absorption
*MUSCLE strength
*BLIND experiment
*LEUCINE
*TUMOR necrosis factors
*ENZYME-linked immunosorbent assay
*DESCRIPTIVE statistics
*REPEATED measures design
*QUESTIONNAIRES
*WHEY proteins
*AMINO acids
*STATISTICAL sampling
*ATHLETIC ability
*CALCIUM
*URINALYSIS
*FRIEDMAN test (Statistics)
*DATA analysis software
*LONGITUDINAL method
*VALINE
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Language
ISSN
1436-6207
Abstract
Purpose: The aim of the present study was to assess the effect of Bacillus coagulans Unique IS-2 supplementation on absorption and utilization of protein in resistance-trained males. Methods: In this double blind, placebo-control trial, resistance-trained males (21.08 ± 2.84 years) were randomized to consume, either 20 g of whey protein powder {80% whey protein concentrate (WPC80), amounting to 15.4 g protein} with 2 billion CFU Bacillus coagulans Unique IS-2 (supplemental group) or 20 g of whey protein powder and lactose instead of Bacillus coagulans (placebo group) once daily for 60 days with a controlled resistance exercise protocol. The whey protein concentrate (WPC-80) given to both groups had a lactose content of 6.8%. Plasma-free amino acids (PFAAs) were determined at baseline, at 30 and 60 days of supplementation. Muscle strength, hypertrophy, VO2 max, and body composition, and other biochemical parameters were assessed at baseline and end line. Results: A positive effect of probiotic Bacillus coagulans Unique IS-2 supplementation was observed on protein absorption as evidenced by an increase in total PFAA by + 16.1% (p = 0.004). Branched chain amino acids (BCAA) comprising isoleucine (p = 0.016), leucine (p = 0.001), and valine (p = 0.002) were increased by + 33.1% in ITT analysis as compared to placebo after 60 days. At 30 days an increase in isoleucine by + 35% (p = 0.113), leucine by + 43% (p = 0.032), and valine by + 32% (p = 0.017) was observed in ITT analysis. Probiotic effect was shown on exercise performance as evidenced by an increase in one RM of leg press and vertical jump power by + 16.61% (p = 0.024) and + 7.86% (p = 0.007), respectively. Conclusion: Significantly increased absorption of BCAA with supplementation of B. coagulans Unique IS-2 along with whey protein and improvement in leg press and vertical jump power was noted indicating the positive effect of the probiotic on muscle power in the lower body. Trial registration number: CTRI/2017/03/008117; Date:16.03.2017. [ABSTRACT FROM AUTHOR]