학술논문

Emerging Role of Antibody-Drug Conjugates and Bispecific Antibodies for the Treatment of Multiple Myeloma.
Document Type
Article
Source
Antibodies (2073-4468). Jun2022, Vol. 11 Issue 2, p22. 19p.
Subject
*BISPECIFIC antibodies
*MULTIPLE myeloma
*ANTIBODY-drug conjugates
*PLASMA cells
*CANCER cells
*PLASMACYTOMA
Language
ISSN
2073-4468
Abstract
Multiple myeloma (MM) is characterized by malignant proliferation of malignant plasma cells; it is the second most common hematological malignancy associated with significant morbidity. Genetic intricacy, instability, and diverse clinical presentations remain a barrier to cure. The treatment of MM is modernized with the introduction of newer therapeutics agents, i.e., target-specific monoclonal antibodies. The currently available literature lacks the benefits of newer targeted therapy being developed with an aim to reduce side effects and increase effectiveness, compared to conventional chemotherapy regimens. This article aims to review literature about the current available monoclonal antibodies, antibody-drug conjugates, and bispecific antibodies for the treatment of MM. [ABSTRACT FROM AUTHOR]