부산대학교 도서관

Melatonin is effective in treating anaemia,7 ischaemia and heart disease,8 and covid-19.9,10 Melatonin may exert these effects by inhibiting PH and increasing HIF. Melatonin increased hypoxia-inducible factor (HIF) by inhibiting prolyl hydroxylase: A hypothesis for treating anaemia, ischaemia, and covid-19 Hypoxia-Inducible Factor (HIF) is a transcriptional factor that acts as an oxygen sensor in the cell and is secreted in the absence of oxygen, leading to improvement of the cell's ability to resist hypoxia.1,2 Interestingly, Gregg L. Semenza won the 2019 Nobel prize in physiology for discovering this vital cell factor as the main agent of cell sensing and adapting to oxygen availability.3 HIF consists of two main parts, HIF- subunit (functional part) and HIF- subunit (structural part), which are constantly transcribed by the nucleus, if the conditions in the cytoplasm are suitable, HIF- and form HIF. Moreover, melatonin inhibits oxidative stress and ROS by affecting melatonin receptor 3 (MT3) and inhibiting electron transfer from quinones in various tissues. [Extracted from the article]