부산대학교 도서관

Background:Chronic obstructive pulmonary disease (COPD) is a common treatable and preventable diseasecharacterized by progressive airflow limitation with an enhanced chronic inflammatory response in the airways.Acute exacerbation of COPD is associated with substantial morbidity and mortality.This study aimed to predict the outcome and future risk of COPD exacerbations and to improve the health quality of COPD patients.Patients and methods: A Cohort prospective study was designed to investigate thirty four hospitalized COPD patients with COPD exacerbation whether in the ward or in the ICU and follow up them for 12 months.Results:Outcome of the exacerbation at admission among the studied patients; 32.4% of had sputum eosinophilia and most of them (76.5%) received LABA as treatment before admission. There was no statistically significant association between eosinophils level at admission and the outcome among the studied group where one patient (9.1%) died among patients with eosinophilia≥2% and also one patient (4.3%) died among patients with eosinophils<2%.Only (31.25%) of the survived patients had sputum eosinophilia(>1.25%), half of them (50.0%) had future single exacerbation, about one third (34.4%) had two exacerbations and (15.6%) had no further exacerbations. all of them (100.0%)received LABA, LAMA and ICS as a triple therapy. There was statistically significant higher TLC, neutrophil count and longer hospital stay among patients with eosinophils<2% than patients with eosinophils ≥2%. But regarding degree of exacerbation, management and outcome, there was no statistically significant difference between patients with low and high eosinophilia. Conclusion:High neutrophil level in peripheral blood duringfollow up period of COPD patients, besides low eosinophil level in both blood and sputum are considered predictor factors for future COPD exacerbations. [ABSTRACT FROM AUTHOR]